Abstract
A qnrB19 gene variant, carried by an IncL/M-like plasmid, was detected in a multidrug Salmonella enterica serovar Typhimurium human strain with reduced susceptibility to ciprofloxacin. The genetic environment around the gene was fully sequenced (20 kb). A large gene cluster, containing the aph, qnrB19, and blaSHV-12-like resistance genes, is inserted inside a Tn3 transposon.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / pharmacology*
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Bacterial Proteins / genetics
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Bacterial Proteins / physiology
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DNA Transposable Elements / genetics
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Drug Resistance, Multiple, Bacterial / genetics*
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Evolution, Molecular
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Microbial Sensitivity Tests
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Multigene Family / genetics
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Plasmids / genetics*
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Quinolones / pharmacology*
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Salmonella typhimurium / drug effects*
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Salmonella typhimurium / genetics*
Substances
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Anti-Bacterial Agents
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Bacterial Proteins
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DNA Transposable Elements
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Quinolones