Abstract
Prolyl hydroxylases (PHDs) perceive intracellular oxygen tension and signal hypoxia-inducible factors (HIFs) to induce hypoxia-adaptive processes such as angiogenesis. A paper from Chan and colleagues in the June issue of Cancer Cell demonstrates that PHD2 inactivation in tumor cells accelerates tumor growth via HIF-independent, NF-kappaB-mediated changes in tumor angiogenesis.
MeSH terms
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Animals
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Cell Proliferation
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Hypoxia-Inducible Factor 1 / metabolism
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Mice
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NF-kappa B / metabolism
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Neoplasms / blood supply
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Neoplasms / enzymology*
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Neoplasms / pathology*
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Neovascularization, Pathologic / enzymology
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Oxygen / metabolism
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Procollagen-Proline Dioxygenase / metabolism*
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Signal Transduction
Substances
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Hypoxia-Inducible Factor 1
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NF-kappa B
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Procollagen-Proline Dioxygenase
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Oxygen