Polymer/silica hybrid hollow nanospheres with pH-sensitive drug release in physiological and intracellular environments

Chem Commun (Camb). 2009 May 21:(19):2718-20. doi: 10.1039/b900751b. Epub 2009 Mar 27.

Abstract

Hybrid hollow nanospheres of chitosan-silica templated by chitosan-poly(acrylic acid) nanoparticles are fabricated in a complete aqueous system, which provide a pH-sensitive switch in physiological and sub-cell environments for the release of loaded drug.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acrylic Resins / chemistry
  • Cell Line, Tumor
  • Cell Survival
  • Chitosan / chemistry
  • Colorectal Neoplasms
  • Doxorubicin / administration & dosage
  • Drug Carriers*
  • Drug Delivery Systems
  • Humans
  • Hydrogen-Ion Concentration
  • Metal Nanoparticles
  • Microscopy, Electron, Transmission
  • Nanospheres / chemistry*
  • Silicon Dioxide

Substances

  • Acrylic Resins
  • Drug Carriers
  • chitosan-poly(acrylic acid)
  • Silicon Dioxide
  • Doxorubicin
  • Chitosan