Abstract
Anchors aweigh! The synthesis of tryptophan-amphotericin B conjugates (see figure) is described. The membrane-anchoring effect of tryptophane was thus combined with the pore-formation effect of amphotericin B leading to high channel activity in sterol-free liposomes.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amphotericin B / chemistry
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Amphotericin B / pharmacology*
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Antifungal Agents / chemical synthesis*
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Antifungal Agents / chemistry
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Antifungal Agents / pharmacology
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Liposomes / chemistry
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Microbial Sensitivity Tests
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Potassium / metabolism
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Tryptophan / chemistry*
Substances
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Antifungal Agents
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Liposomes
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Amphotericin B
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Tryptophan
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Potassium