Efficacy of fluoroquinolones against pathogenic oral bacteria

Mini Rev Med Chem. 2009 Sep;9(10):1147-58. doi: 10.2174/138955709789055243.

Abstract

This article reviews the characteristics of the main fluoroquinolones used in dentistry (ciprofloxacin, levofloxacin and moxifloxacin), including pharmacokinetic/ pharmacodynamic parameters, susceptibility profiles of oral bacteria and clinical trials on their efficacy in dental practice. It seems that some of these antibiotics might represent a safe alternative in patients with allergy, intolerance, or lack of response to beta-lactams.

Publication types

  • Review

MeSH terms

  • Aza Compounds / chemistry
  • Aza Compounds / pharmacokinetics
  • Aza Compounds / pharmacology
  • Aza Compounds / therapeutic use*
  • Bacteria / drug effects
  • Bacterial Infections / drug therapy*
  • Ciprofloxacin / chemistry
  • Ciprofloxacin / pharmacokinetics
  • Ciprofloxacin / pharmacology
  • Ciprofloxacin / therapeutic use*
  • Fluoroquinolones / chemistry
  • Fluoroquinolones / pharmacokinetics
  • Fluoroquinolones / pharmacology
  • Fluoroquinolones / therapeutic use*
  • Humans
  • Levofloxacin*
  • Mouth Diseases / drug therapy*
  • Moxifloxacin
  • Ofloxacin / chemistry
  • Ofloxacin / pharmacokinetics
  • Ofloxacin / pharmacology
  • Ofloxacin / therapeutic use*
  • Oral Medicine*
  • Quinolines / chemistry
  • Quinolines / pharmacokinetics
  • Quinolines / pharmacology
  • Quinolines / therapeutic use*

Substances

  • Aza Compounds
  • Fluoroquinolones
  • Quinolines
  • Ciprofloxacin
  • Levofloxacin
  • Ofloxacin
  • Moxifloxacin