Abstract
The paper presents the data of a comparative analysis of various bioinformation methods for evaluating the tropism of HIV-1 subtype A that is typical of Russia. The prevalence of CXCR4- and CCR5-tropic viruses among the variants prevailing in Russia was studied using the B-PSSM (sinsi) prediction method. No X4-tropic variants were found among 124 samples of HIV-1 isolated from the Russian patients not receiving antiretrovirus therapy.
Publication types
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Comparative Study
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English Abstract
MeSH terms
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Cell Line, Tumor
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Computational Biology / methods*
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HIV Envelope Protein gp120 / genetics
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HIV Infections / epidemiology*
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HIV Infections / virology*
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HIV-1 / classification
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HIV-1 / genetics
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HIV-1 / physiology*
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Humans
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Peptide Fragments / genetics
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RNA, Viral / genetics
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Receptors, CCR5 / physiology*
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Receptors, CXCR4 / physiology*
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Russia / epidemiology
Substances
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HIV Envelope Protein gp120
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HIV envelope protein gp120 (305-321)
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Peptide Fragments
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RNA, Viral
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Receptors, CCR5
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Receptors, CXCR4