Abstract
The authors report on a case of voluminous perforated gastrointestinal stromal tumor (GIST) of small intestine and make a review to the light of most recent clinicopathologic advancements. The first clinical manifestation as acute abdomen due to their perforation extremely rare. Gastrointestinal stromal tumor (GIST) represent a rare group of multiform tumors with various biological behaviour. Were identified in the past as leiomyomas, leiomyosarcomas or leiomyoblastomas, has been reclassified on immunochemical features, with a positive expression of Kit (CD117 antigen). Traditionally the prognostic factors of these tumour are: mitotic rate, tumor size and anatomic site. The complete surgical resection and use of imatinib mesylate (Gleevec) are the best available approach.
Publication types
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Case Reports
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English Abstract
MeSH terms
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Abdomen, Acute / drug therapy
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Abdomen, Acute / etiology*
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Abdomen, Acute / pathology
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Abdomen, Acute / surgery
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use
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Biomarkers, Tumor / analysis
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Diagnosis, Differential
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Gastrointestinal Stromal Tumors / complications*
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Gastrointestinal Stromal Tumors / drug therapy
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Gastrointestinal Stromal Tumors / pathology
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Gastrointestinal Stromal Tumors / surgery
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Humans
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Intestinal Perforation / complications*
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Intestinal Perforation / drug therapy
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Intestinal Perforation / etiology
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Intestinal Perforation / pathology
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Intestinal Perforation / surgery
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Jejunal Neoplasms / complications*
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Jejunal Neoplasms / drug therapy
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Jejunal Neoplasms / pathology
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Jejunal Neoplasms / surgery
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Male
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Middle Aged
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Proto-Oncogene Proteins c-kit / analysis
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Treatment Outcome
Substances
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Biomarkers, Tumor
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Proto-Oncogene Proteins c-kit