Intracellular life of Coxiella burnetii in macrophages

Ann N Y Acad Sci. 2009 May:1166:55-66. doi: 10.1111/j.1749-6632.2009.04515.x.

Abstract

Coxiella burnetii, the agent of Q fever, is an obligate intracellular bacterium that is considered a potential biological weapon of category B. C. burnetii survives within myeloid cells by subverting receptor-mediated phagocytosis and preventing phagosome maturation. The intracellular fate of C. burnetii also depends on the functional state of myeloid cells. This review describes the mechanisms used by C. burnetii to circumvent uptake and trafficking events, and the role of cytokines on C. burnetii survival in myeloid cells.

Publication types

  • Review

MeSH terms

  • Animals
  • Bacterial Proteins / genetics
  • Bacterial Proteins / metabolism
  • Coxiella burnetii / genetics
  • Coxiella burnetii / metabolism*
  • Coxiella burnetii / pathogenicity*
  • Cytokines / immunology
  • Cytoskeleton / metabolism
  • Granuloma / immunology
  • Granuloma / microbiology
  • Granuloma / pathology
  • Humans
  • Integrins / metabolism
  • Interleukin-10 / immunology
  • Macrophages / cytology
  • Macrophages / metabolism
  • Macrophages / microbiology*
  • Myeloid Cells / cytology
  • Myeloid Cells / metabolism
  • Myeloid Cells / microbiology
  • Phagocytosis / physiology
  • Phagosomes / metabolism*
  • Phagosomes / microbiology
  • Q Fever / immunology
  • Q Fever / microbiology
  • Q Fever / pathology
  • Q Fever / transmission
  • Toll-Like Receptors / immunology
  • Virulence Factors / genetics
  • Virulence Factors / metabolism

Substances

  • Bacterial Proteins
  • Cytokines
  • Integrins
  • Toll-Like Receptors
  • Virulence Factors
  • Interleukin-10