PLZF outreach: a finger in interferon's pie

Immunity. 2009 Jun 19;30(6):757-8. doi: 10.1016/j.immuni.2009.06.003.

Abstract

In this issue of Immunity, Xu et al. (2009) find that the transcription factor PLZF activates interferon-stimulated genes and facilitates natural killer cell functions. Interferon-induced PLZF phosphorylation and histone deacetylase 1 recruitment probably mediates the repressor-to-activator conversion.

Publication types

  • Comment

MeSH terms

  • Animals
  • Histone Deacetylases / immunology
  • Histone Deacetylases / metabolism*
  • Humans
  • Immunity, Innate
  • Interferons / immunology
  • Interferons / metabolism*
  • Killer Cells, Natural / immunology
  • Kruppel-Like Transcription Factors / genetics
  • Kruppel-Like Transcription Factors / metabolism*
  • Promyelocytic Leukemia Zinc Finger Protein
  • Repressor Proteins / genetics
  • Repressor Proteins / metabolism*

Substances

  • Kruppel-Like Transcription Factors
  • Promyelocytic Leukemia Zinc Finger Protein
  • Repressor Proteins
  • Zbtb16 protein, mouse
  • ZBTB16 protein, human
  • Interferons
  • Histone Deacetylases