Sunitinib inducing tumor lysis syndrome in a patient treated for renal carcinoma

Invest New Drugs. 2010 Oct;28(5):690-3. doi: 10.1007/s10637-009-9275-z. Epub 2009 Jun 24.

Abstract

Sunitinib is an oral antityrosine kinase inhibitor that has antiangiogenic and antitumor activities. It has been approved for the treatment of advanced RCC and for imatinib-refractory gastrointestinal stromal tumors (GIST). Tumor lysis syndrom can occur in solid tumors. We report a case of patient with metastatic RCC treated with sunitinib with a diagnosis of tumor lysis syndrome.

Publication types

  • Case Reports

MeSH terms

  • Angiogenesis Inhibitors / adverse effects*
  • Angiogenesis Inhibitors / therapeutic use*
  • Humans
  • Indoles / adverse effects*
  • Indoles / therapeutic use*
  • Kidney Neoplasms / complications
  • Kidney Neoplasms / diagnostic imaging
  • Kidney Neoplasms / drug therapy*
  • Male
  • Middle Aged
  • Pyrroles / adverse effects*
  • Pyrroles / therapeutic use*
  • Sunitinib
  • Tomography, X-Ray Computed
  • Tumor Lysis Syndrome / diagnostic imaging
  • Tumor Lysis Syndrome / etiology*
  • Ultrasonography

Substances

  • Angiogenesis Inhibitors
  • Indoles
  • Pyrroles
  • Sunitinib