Abstract
Fifteen patients suspected of having iNPH were clinically evaluated and their ApoE genotype determined prior to a possible ventriculoperitoneal shunt insertion. All patients fulfilling our criteria for intervention and who had a shunt implanted with good results were homozygous for the ApoE3/3 genotype.
MeSH terms
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Aged
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Aged, 80 and over
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Apolipoprotein E3 / genetics
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Apolipoproteins E / genetics*
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Brain / metabolism
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Brain / physiopathology
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Cerebrospinal Fluid Shunts
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DNA Mutational Analysis
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Dementia / etiology
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Dementia / physiopathology
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Female
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Gait Disorders, Neurologic / etiology
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Gait Disorders, Neurologic / physiopathology
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Gene Frequency / genetics
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Genetic Markers / genetics
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Genetic Predisposition to Disease / genetics*
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Genetic Testing
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Genotype
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Homozygote
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Humans
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Hydrocephalus, Normal Pressure / genetics*
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Hydrocephalus, Normal Pressure / physiopathology*
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Hydrocephalus, Normal Pressure / surgery
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Male
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Middle Aged
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Prognosis
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Treatment Outcome
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Urinary Incontinence / etiology
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Urinary Incontinence / physiopathology
Substances
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Apolipoprotein E3
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Apolipoproteins E
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Genetic Markers