Abstract
In this Letter we report the synthesis and in vitro studies of cleavable polymer-drug conjugates derived from dendritic polyglycerol and maleimide-bearing prodrugs of doxorubicin and methotrexate that are cleaved by cathepsin B. Cleavage properties and cytotoxicity of the new conjugates are presented.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Antineoplastic Agents / administration & dosage*
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / pharmacology
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Cathepsin B / metabolism
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Cell Line, Tumor
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Dendrimers / chemistry
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Doxorubicin / chemistry
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Drug Carriers / chemical synthesis*
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Drug Carriers / chemistry
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Drug Screening Assays, Antitumor
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Glycerol / chemistry*
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Humans
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Maleimides / chemistry
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Methotrexate / chemistry
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Polymers / chemistry*
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Prodrugs / administration & dosage*
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Prodrugs / chemistry
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Prodrugs / pharmacology
Substances
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Antineoplastic Agents
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Dendrimers
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Drug Carriers
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Maleimides
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Polymers
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Prodrugs
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maleimide
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polyglycerol
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Doxorubicin
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Cathepsin B
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Glycerol
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Methotrexate