Abstract
A series of indole amidines modified at the 2-position of the indole ring were evaluated as inhibitors of Acid-Sensing Ion Channel-3 (ASIC3), a novel target for the treatment of chronic pain.
MeSH terms
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Acid Sensing Ion Channels
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Amidines / chemistry*
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Animals
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Chemistry, Pharmaceutical / methods*
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Drug Design
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Electrophysiology
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Indoles / chemistry
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Inhibitory Concentration 50
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Ion Channels / chemistry
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Male
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Models, Chemical
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Naproxen / pharmacology
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Rats
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Rats, Sprague-Dawley
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Sodium Channels / chemistry*
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Structure-Activity Relationship
Substances
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ASIC3 protein, human
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Acid Sensing Ion Channels
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Amidines
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Indoles
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Ion Channels
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Sodium Channels
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Naproxen