Abstract
Four new labdane diterpene glycosides (1-4) named alpindenosides A, B, C, and D, two new norditerpene glycosides (5, 6) named noralpindenosides A and B, and three known flavonoid glycosides (7-9) have been isolated from the stems of Alpinia densespicata. Structural elucidation of compounds 1-6 was based on spectroscopic data. Compounds 1-9 all exhibited moderate NO inhibitory activities, whereas they were noncytotoxic at 20 microM against several human tumor cell lines.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alpinia / chemistry*
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Animals
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Diterpenes / chemistry
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Diterpenes / isolation & purification*
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Diterpenes / pharmacology*
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Drug Screening Assays, Antitumor
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Drugs, Chinese Herbal / chemistry
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Drugs, Chinese Herbal / isolation & purification*
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Drugs, Chinese Herbal / pharmacology*
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Glycosides / chemistry
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Glycosides / pharmacology
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HeLa Cells
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Humans
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KB Cells
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Lipopolysaccharides / pharmacology
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Macrophages / drug effects*
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Mice
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Molecular Structure
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Nitric Oxide / antagonists & inhibitors*
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Nuclear Magnetic Resonance, Biomolecular
Substances
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Diterpenes
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Drugs, Chinese Herbal
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Glycosides
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Lipopolysaccharides
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labdane
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Nitric Oxide