Representation of internal models of action in the autistic brain

Nat Neurosci. 2009 Aug;12(8):970-2. doi: 10.1038/nn.2356. Epub 2009 Jul 5.

Abstract

Children with autism spectrum disorder (ASD) have deficits in motor control, imitation and social function. Does a dysfunction in the neural basis of representing internal models of action contribute to these problems? We measured patterns of generalization as children learned to control a novel tool and found that the autistic brain built a stronger than normal association between self-generated motor commands and proprioceptive feedback; furthermore, the greater the reliance on proprioception, the greater the child's impairments in social function and imitation.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Autistic Disorder / complications
  • Autistic Disorder / physiopathology*
  • Autistic Disorder / psychology
  • Brain / physiopathology*
  • Child
  • Disability Evaluation
  • Feedback / physiology
  • Female
  • Humans
  • Imitative Behavior / physiology
  • Learning / physiology
  • Male
  • Models, Neurological
  • Motor Skills / physiology
  • Movement / physiology*
  • Movement Disorders / etiology
  • Movement Disorders / physiopathology*
  • Movement Disorders / psychology
  • Proprioception / physiology
  • Psychomotor Performance / physiology*
  • Social Behavior Disorders / etiology
  • Social Behavior Disorders / physiopathology*
  • Social Behavior Disorders / psychology