Abstract
Two new and three previously known CIS-clerodane diterpenoids were isolated from the wild liverwort Gottschelia schizopleura (Jungermanniales, Jungermanniaceae). Their structures were established on the basis of spectroscopic analysis, especially 1D and 2D NMR data. The cytotoxic activities of compounds 1- 5 were evaluated against liver hepatoblastoma (HEP-G2), lung carcinoma (A549), breast ductal carcinoma (MDA-MB-435), and colon adenocarcinoma (LOVO) cell lines. Compound 1 showed moderate inhibition against MDA-MB-435 and LOVO cells.
Georg Thieme Verlag KG Stuttgart. New York.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents, Phytogenic / isolation & purification*
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Antineoplastic Agents, Phytogenic / pharmacology
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Antineoplastic Agents, Phytogenic / therapeutic use
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Cell Line, Tumor
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Diterpenes / isolation & purification
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Diterpenes / pharmacology
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Diterpenes / therapeutic use
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Diterpenes, Clerodane / isolation & purification
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Diterpenes, Clerodane / pharmacology
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Diterpenes, Clerodane / therapeutic use
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Hepatophyta / chemistry*
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Humans
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Molecular Structure
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Neoplasms / drug therapy*
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Plant Extracts / chemistry*
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Plant Extracts / pharmacology
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Plant Extracts / therapeutic use
Substances
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Antineoplastic Agents, Phytogenic
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Diterpenes
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Diterpenes, Clerodane
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Plant Extracts