Pneumococcal LytR, a protein from the LytR-CpsA-Psr family, is essential for normal septum formation in Streptococcus pneumoniae

Ola Johnsborg; Leiv Sigve Håvarstein

doi:10.1128/JB.00724-09

Pneumococcal LytR, a protein from the LytR-CpsA-Psr family, is essential for normal septum formation in Streptococcus pneumoniae

J Bacteriol. 2009 Sep;191(18):5859-64. doi: 10.1128/JB.00724-09. Epub 2009 Jul 6.

Authors

Ola Johnsborg¹, Leiv Sigve Håvarstein

Affiliation

¹ Department of Chemistry, Biotechnology, and Food Science, Norwegian University of Life Sciences, P.O. Box 5003, N-1432 As, Norway. [email protected]

Abstract

Proliferation of the human-pathogenic bacterium Streptococcus pneumoniae is fundamentally linked to the bacterial proteins that function in cell division. Here, we show that LytR, a pneumococcal protein from the LytR-CpsA-Psr family, is essential to this process.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Bacterial Proteins / classification
Bacterial Proteins / genetics
Bacterial Proteins / metabolism*
Cell Division*
Culture Media
Gene Expression Regulation, Bacterial*
Humans
Microscopy, Electron, Scanning
Microscopy, Electron, Transmission
Mutation
Streptococcus pneumoniae / cytology*
Streptococcus pneumoniae / genetics
Streptococcus pneumoniae / metabolism
Streptococcus pneumoniae / ultrastructure
Transcription Factors / classification
Transcription Factors / genetics
Transcription Factors / metabolism*

Substances

Bacterial Proteins
CpsA protein, Streptococcus pneumoniae
Culture Media
Transcription Factors