Abstract
Nosocomial outbreaks attributable to glutaraldehyde-resistant, rapidly growing mycobacteria are increasing. Here, evidence is provided that defects in porin expression dramatically increase the resistance of Mycobacterium smegmatis and Mycobacterium chelonae to glutaraldehyde and another aldehyde disinfectant, ortho-phthalaldehyde. Since defects in porin activity also dramatically increased the resistance of M. chelonae to drugs, there is thus some concern that the widespread use of glutaraldehyde and ortho-phthalaldehyde in clinical settings may select for drug-resistant bacteria.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antitubercular Agents / pharmacology*
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Disinfectants / pharmacology*
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Drug Resistance, Bacterial / genetics
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Glutaral / pharmacology*
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Microbial Sensitivity Tests
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Molecular Sequence Data
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Mutation
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Mycobacterium chelonae / drug effects*
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Mycobacterium chelonae / genetics*
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Mycobacterium smegmatis / drug effects*
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Mycobacterium smegmatis / genetics*
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Porins / genetics
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Porins / physiology*
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o-Phthalaldehyde / pharmacology
Substances
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Antitubercular Agents
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Disinfectants
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Porins
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o-Phthalaldehyde
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Glutaral
Associated data
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GENBANK/FJ981588
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GENBANK/FJ981589
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GENBANK/FJ981590