Abstract
We evaluated the possible association of human leukocyte antigen-G (HLA-G) 3777G>C and 14-bp deletion/insertion (D/I) polymorphisms haplotypes and combined genotypes with perinatal HIV transmission in Brazilian children. The 3777G>C polymorphism alone has no effect on HIV vertical transmission but, when linked with the D allele, exerts a positive role in the protection. Indeed, we identified the DC HLA-G haplotype as significantly associated with a protective effect towards HIV vertical transmission.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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3' Untranslated Regions / genetics*
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Child
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Child, Preschool
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Female
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Gene Deletion
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Gene Frequency
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Genetic Predisposition to Disease
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HIV Infections / genetics
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HIV Infections / transmission*
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HIV Infections / virology
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HIV-1*
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HLA Antigens / genetics*
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HLA-G Antigens
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Haplotypes
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Histocompatibility Antigens Class I / genetics*
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Humans
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Infectious Disease Transmission, Vertical*
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Linkage Disequilibrium
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Male
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Polymorphism, Genetic
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Pregnancy
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Prenatal Exposure Delayed Effects
Substances
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3' Untranslated Regions
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HLA Antigens
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HLA-G Antigens
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Histocompatibility Antigens Class I