The objective was to study antibiotics prescribing in Cotonou health care centres. This prospective study was conducted in two phases. The first consisted in collecting antibiotics prescriptions. In a second phase, the prescriptions were submitted to 4 experts who assessed the correctness of the prescribing. Out of the 588 prescriptions that could be analysed, 173 (29.4%) were correct The quality of the prescribing seems to depend only on the pathology but not on the nature of the basic training of the prescriber