Cell-induced intracellular controlled release of membrane impermeable cysteine from a mesoporous silica nanoparticle-based drug delivery system

Chem Commun (Camb). 2009 Jun 14:(22):3219-21. doi: 10.1039/b900559e. Epub 2009 May 7.

Abstract

A mesoporous silica nanoparticle-based intracellular cysteine delivery system that could be induced and regulated by cell-produced natural antioxidants was synthesized.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Antioxidants / metabolism
  • Cell Membrane Permeability*
  • Cell Proliferation / drug effects
  • Cysteine / chemistry
  • Cysteine / metabolism*
  • Cysteine / pharmacology
  • Drug Carriers / chemistry*
  • HeLa Cells
  • Humans
  • Intracellular Space / metabolism*
  • Metal Nanoparticles / chemistry*
  • Porosity
  • Silicon Dioxide / chemistry*

Substances

  • Antioxidants
  • Drug Carriers
  • Silicon Dioxide
  • Cysteine