Abstract
A series of 30 tripeptides were synthesized and tested as novel 5-HT4 receptor ligands. Receptor binding assays showed that a subset of compounds had reasonable potency relative to the agonists serotonin and 5-methoxytryptamine. Structure-activity analyses and molecular docking have highlighted avenues for further synthetic work.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Biogenic Amines / metabolism
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Drug Discovery*
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Humans
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Ligands
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Models, Molecular
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Oligopeptides / chemistry*
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Oligopeptides / metabolism*
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Receptors, Serotonin, 5-HT4 / chemistry
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Receptors, Serotonin, 5-HT4 / metabolism*
Substances
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Biogenic Amines
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Ligands
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Oligopeptides
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Receptors, Serotonin, 5-HT4