An extended genetic recombination map for foot-and-mouth diseases virus

J Gen Virol. 1977 Jun;35(3):555-65. doi: 10.1099/0022-1317-35-3-555.

Abstract

The original foot-and-mouth diseases virus recombination map (Lake, Priston & Slade, 1975), which include 35 mutagen-induced ts mutants, has been extended both in detail and size by the mapping of a further 33 ts mutants (9 mutagen-induced and 24 spontaneous). The size increase from 0.57% to 3.27% maximum recombination fequency was principally due to the use of a new standardization technique for recombination fequencies but, in addition, the original map distance was increased by approx. 30% due to the mapping of new mutations. As in the original map, there was a marked concentration of mutations near the guanidine (gs) locus, i.e. 83% of the mutants had mutations in the third of the map adjacent to the gs locus.

MeSH terms

  • Aphthovirus* / drug effects
  • Chromosome Mapping*
  • Drug Resistance, Microbial
  • Fluorouracil
  • Genes*
  • Guanidines / pharmacology
  • Hydroxylamines
  • Mutagens
  • Mutation
  • Recombination, Genetic

Substances

  • Guanidines
  • Hydroxylamines
  • Mutagens
  • Fluorouracil