Applications of bioinformatics to protein structures: how protein structure and bioinformatics overlap

Methods Mol Biol. 2009:569:157-72. doi: 10.1007/978-1-59745-524-4_8.

Abstract

In this chapter, we will focus on the role of bioinformatics to analyze a protein after its protein structure has been determined. First, we present how to validate protein structures for quality assurance. Then, we discuss how to analyze protein-protein interfaces and how to predict the biomolecule which is the biological oligomeric state of the protein. Finally, we discuss how to search for homologs based on the 3-D structure which is an essential step for understanding protein function.

Publication types

  • Comparative Study
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Computational Biology*
  • Databases, Protein
  • Protein Interaction Domains and Motifs
  • Protein Interaction Mapping / statistics & numerical data
  • Proteins / chemistry*
  • Software
  • Structural Homology, Protein

Substances

  • Proteins