The new HLA-Cw*0524 allele increase the variability of position 49 in HLA-C

C Figueiredo; Y Jaimes; P A Horn; R Blasczyk; B Eiz-Vesper

doi:10.1111/j.1399-0039.2009.01310.x

The new HLA-Cw*0524 allele increase the variability of position 49 in HLA-C

Tissue Antigens. 2009 Sep;74(3):258-9. doi: 10.1111/j.1399-0039.2009.01310.x. Epub 2009 Jul 13.

Authors

C Figueiredo¹, Y Jaimes, P A Horn, R Blasczyk, B Eiz-Vesper

Affiliation

¹ Institute for Transfusion Medicine, Hannover Medical School, Hannover, Germany.

PMID: 19624482
DOI: 10.1111/j.1399-0039.2009.01310.x

Abstract

The identification of the novel human leukocyte antigen (HLA)-Cw*0524, which was found in a potential stem cell donor, is described. The sequence of the new allele differs from HLA-Cw*0501 and HLA-Cw*0503 by a nonsynonymous amino acid (AA) exchanges at position 49.

MeSH terms

Alleles*
Amino Acid Sequence
Amino Acid Substitution
Base Sequence
Exons
Genetic Variation*
Glycine / metabolism
HLA-C Antigens / chemistry
HLA-C Antigens / genetics*
Haplotypes
Histocompatibility Antigens Class I / genetics
Histocompatibility Antigens Class II / genetics
Histocompatibility Testing
Humans
Molecular Sequence Data
Polymorphism, Genetic
Protein Structure, Tertiary / genetics
Stem Cells / cytology
Terminology as Topic
Tissue Donors

Substances

HLA-C Antigens
Histocompatibility Antigens Class I
Histocompatibility Antigens Class II
Glycine