Isopimarane diterpenoids from Aeollanthus rydingianus and their antimicrobial activity

Phytochemistry. 2009 Jun;70(9):1161-1165. doi: 10.1016/j.phytochem.2009.06.008. Epub 2009 Jul 22.

Abstract

Four acyloxy-isopimarane derivatives along with two known isopimarane diterpenoids, the flavone cirsimaritin and the sterols beta-sitosterol and stigmasterol were isolated from the aerial parts of Aeollanthus rydingianus. The structures of the compounds were established on the basis of spectroscopic analysis and chemical evidence. The isolated substances were screened for antimicrobial activity against Gram-positive and Gram-negative bacteria and a yeast strain. 19-Acetoxy-7,15-isopimaradien-3beta-ol and 7,15-isopimaradien-19-ol showed minimum inhibitory concentration (MIC) values of 3.90-15.62 microg/ml for Staphylococcus aureus and of 7.81microg/ml for Enterococcus hirae.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents* / chemistry
  • Anti-Bacterial Agents* / isolation & purification
  • Anti-Bacterial Agents* / pharmacology
  • Diterpenes* / chemistry
  • Diterpenes* / isolation & purification
  • Diterpenes* / pharmacology
  • Enterococcus / drug effects
  • Gram-Negative Bacteria / drug effects
  • Gram-Positive Bacteria / drug effects
  • Lamiaceae / chemistry*
  • Microbial Sensitivity Tests
  • Molecular Structure
  • Plants, Medicinal / chemistry*
  • Sitosterols
  • Staphylococcus aureus / drug effects
  • Vancomycin / pharmacology

Substances

  • Anti-Bacterial Agents
  • Diterpenes
  • Sitosterols
  • gamma-sitosterol
  • Vancomycin