Abstract
The response of convergent dorsal horn cells to tonic and phasic noxious heating and to noxious pinching was studied before and after topical application of a solution (30 nmol) of the kappa agonist U-50,488H to the dorsal surface of the spinal cord. U-50,488H depressed the discharge of convergent units evoked by thermal and mechanical nociceptive stimuli. The opiate antagonist WIN 44,441-3 reversed the effect of U-50,488H. It is concluded that kappa opioids are effective in preventing the depolarization of convergent dorsal horn neurons evoked by either thermal or non-thermal noxious stimuli.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer
-
Analgesics / pharmacology
-
Animals
-
Anterior Horn Cells / drug effects
-
Anterior Horn Cells / physiology*
-
Azocines / pharmacology
-
Hot Temperature
-
Narcotic Antagonists / pharmacology
-
Nociceptors / physiology
-
Physical Stimulation
-
Pyrrolidines / pharmacology
-
Rats
-
Rats, Inbred Strains
-
Receptors, Opioid / physiology*
-
Receptors, Opioid, kappa
-
Synaptic Transmission / physiology
Substances
-
Analgesics
-
Azocines
-
Narcotic Antagonists
-
Pyrrolidines
-
Receptors, Opioid
-
Receptors, Opioid, kappa
-
3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer
-
quadazocine