Abstract
Disturbed function of the hypothalamic-pituitary axis at adrenal and thyroid levels was found during an episode of hypersomnia in the idiopathic recurring hypersomnia syndrome. These endocrinological abnormalities, abolished ACTH and cortisol responses to insulin-induced hypoglycemia and absent TSH response to TRH, normalised thereafter in the symptom-free interval. These data support the hypothesis that Kleine-Levin syndrome is related to an intermittent hypothalamic dysfunction.
MeSH terms
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Adolescent
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Adrenocorticotropic Hormone
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Blood Glucose / metabolism
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Disorders of Excessive Somnolence / blood*
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Encephalitis / blood
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Follicle Stimulating Hormone / blood
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Gonadotropin-Releasing Hormone
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Humans
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Hydrocortisone / blood*
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Hypothalamo-Hypophyseal System / physiopathology*
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Insulin
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Luteinizing Hormone / blood
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Male
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Neurocognitive Disorders / blood
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Recurrence
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Syndrome
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Thyrotropin / blood*
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Thyrotropin-Releasing Hormone
Substances
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Blood Glucose
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Insulin
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Gonadotropin-Releasing Hormone
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Thyrotropin-Releasing Hormone
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Adrenocorticotropic Hormone
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Luteinizing Hormone
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Follicle Stimulating Hormone
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Thyrotropin
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Hydrocortisone