gem-Dimethyl 4-pentenyl glycosides: novel glycosylating agents and anomeric protecting groups

Org Lett. 2009 Aug 20;11(16):3594-7. doi: 10.1021/ol901313z.

Abstract

Two classes of gem-dimethyl 4-n-pentenyl glycosides (i.e., C2-series and C3-series) have been prepared and studied in both the glycosylation and hydrolysis manifolds utilizing NBS as the sole stoichiometric activator. These novel glycosylating agents, which are analogues of Fraser-Reid's 4-n-pentenyl glycosyl donors, show increased reactivity in side-by-side studies by virtue of the gem-dimethyl effect.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Glycosides / chemical synthesis*
  • Glycosides / chemistry
  • Glycosylation
  • Hydrolysis
  • Molecular Structure
  • Stereoisomerism

Substances

  • Glycosides