Abstract
A series of 9-methoxy-6H-[1]benzothiopyrano[4,3-b]quinolin-10-ols with a Mannich side chain were synthesized and evaluated for their anti-Hepatitis B virus (HBV) activity in HepG2.2.15 cells. Some compounds showed significant anti-HBV activity with IC(50) values less than 41 microM. Among them, compound 9b was the most effective anti-HBV agent (IC(50) = 1.7 microM, SI = 60.3).
MeSH terms
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Antiviral Agents / chemical synthesis*
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Antiviral Agents / chemistry
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Antiviral Agents / pharmacology
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Cell Line
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Cell Survival / drug effects*
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DNA, Viral / metabolism
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Drug Evaluation, Preclinical
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Drug Resistance, Viral
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Hepatitis B virus / drug effects*
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Hepatitis B virus / metabolism
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Hydroxyquinolines / pharmacology*
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Lamivudine / pharmacology
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Molecular Structure
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Structure-Activity Relationship
Substances
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Antiviral Agents
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DNA, Viral
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Hydroxyquinolines
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Lamivudine