Abstract
Signaling through the transcription factor nuclear factor kappaB (NF-kappaB) regulates various physiological processes, including immune responses and inflammation. An analysis of NF-kappaB dynamics suggests that the oscillation frequency of NF-kappaB activation determines which downstream genes are expressed, enabling a single pathway to respond to diverse stimuli in distinct ways.
MeSH terms
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Active Transport, Cell Nucleus
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Animals
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Cell Nucleus / metabolism
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Enzyme Activation
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Humans
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I-kappa B Kinase / metabolism*
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I-kappa B Proteins / genetics
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I-kappa B Proteins / metabolism
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Models, Biological
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NF-KappaB Inhibitor alpha
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NF-kappa B / metabolism*
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Signal Transduction / physiology*
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Transcriptional Activation
Substances
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I-kappa B Proteins
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NF-kappa B
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NFKBIA protein, human
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NF-KappaB Inhibitor alpha
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I-kappa B Kinase