Cellular morphology has a predominant place in diagnosis of hematological malignancies in spite of flow cytometry, cytogenetic and molecular biology progresses. CellaVisionDM8/96TM is automated microscope and image analysis software which are able to characterize white and red blood cells morphology and to perform platelets counts in peripheral blood smears. Validity of results is always submitted to the cytologist agreement. We routinely analyzed 99 peripheral blood smears, included 9 therapeutic cytopenias, stained with May-Grünwald-Giemsa. DM8/96TM is highly efficient in the cellular identification with great security of identity management and timesaving (30% faster than manual microscopy). Major innovations are the complete slides recording, efficiency on cytopenias processing, education functionalities and the networking ability.