Intracavity wavelength modulation of an optical parametric oscillator for coherent Raman microscopy

Opt Express. 2009 Jul 20;17(15):12532-9. doi: 10.1364/oe.17.012532.

Abstract

We present a novel intracavity frequency modulation scheme in a tunable, picosecond optical parametric oscillator (OPO). The OPO signal wavelength can be modulated with a depth of more than 10 nm at a rate of 38 MHz (one half its repetition rate). We discuss the design and construction of the light source and its application to the recently-developed frequency modulation coherent anti-Stokes Raman scattering (FM-CARS) and stimulated Raman scattering (SRS) techniques. The new light source allows for real time subtraction of the interfering background signal in coherent Raman imaging, yielding images with purely chemical contrast.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Equipment Design
  • Hair
  • Lasers
  • Light
  • Mice
  • Microscopy / methods*
  • Minoxidil / pharmacology
  • Optics and Photonics
  • Oscillometry / methods*
  • Physics / methods
  • Scattering, Radiation
  • Skin / pathology
  • Spectrum Analysis, Raman / methods*
  • Time Factors

Substances

  • Minoxidil