Regulation of intestinal iron absorption: the mucosa takes control?

Robert J Simpson; Andrew T McKie

doi:10.1016/j.cmet.2009.06.009

Regulation of intestinal iron absorption: the mucosa takes control?

Cell Metab. 2009 Aug;10(2):84-7. doi: 10.1016/j.cmet.2009.06.009.

Authors

Robert J Simpson¹, Andrew T McKie

Affiliation

¹ Kings College London, Division of Nutritional Sciences, London, UK.

PMID: 19656486
DOI: 10.1016/j.cmet.2009.06.009

Abstract

Two studies (Shah et al., 2009; Mastrogiannaki et al., 2009) show that the hypoxia inducible factor HIF-2alpha is a major player in regulating iron absorption by directly controlling the transcription of iron transporters in the intestine in response to changes in mucosal iron or oxygen levels. The HIF-2alpha mechanism has major effects on iron metabolism which can override the well-known hepcidin-ferroportin regulatory axis.

Publication types

Review

MeSH terms

Animals
Antimicrobial Cationic Peptides / metabolism
Basic Helix-Loop-Helix Transcription Factors / genetics
Basic Helix-Loop-Helix Transcription Factors / metabolism
Cation Transport Proteins / metabolism
Ferroportin
Hepcidins
Hypoxia-Inducible Factor 1 / genetics
Hypoxia-Inducible Factor 1 / metabolism
Intestinal Absorption*
Intestinal Mucosa / physiology*
Iron / metabolism*
Mice

Substances

Antimicrobial Cationic Peptides
Basic Helix-Loop-Helix Transcription Factors
Cation Transport Proteins
Hamp protein, mouse
Hepcidins
Hypoxia-Inducible Factor 1
Ferroportin
endothelial PAS domain-containing protein 1
Iron