Abstract
The antiviral effect of ganciclovir and foscarnet encapsulated in liposomes was studied against cytomegalovirus in human embryonic lung fibroblast cells. Substantially greater activity (3.5-fold and 38-fold respectively) in terms of inhibition of virus replication intracellularly was found compared to that seen with non-encapsulated antiviral agents, and liposome encapsulation did not result in increased cytotoxicity.
MeSH terms
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Antiviral Agents / administration & dosage
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Antiviral Agents / pharmacology*
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Antiviral Agents / toxicity
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Cells, Cultured
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Cytomegalovirus / drug effects*
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Cytomegalovirus / physiology
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Drug Carriers
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Fibroblasts / drug effects
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Fibroblasts / microbiology
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Foscarnet
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Ganciclovir / administration & dosage
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Ganciclovir / pharmacology*
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Ganciclovir / toxicity
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Humans
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Liposomes
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Phosphonoacetic Acid / administration & dosage
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Phosphonoacetic Acid / analogs & derivatives*
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Phosphonoacetic Acid / pharmacology
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Phosphonoacetic Acid / toxicity
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Viral Plaque Assay
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Virus Replication / drug effects
Substances
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Antiviral Agents
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Drug Carriers
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Liposomes
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Foscarnet
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Phosphonoacetic Acid
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Ganciclovir