Smooth(ing) muscle differentiation by microRNAs

Cell Stem Cell. 2009 Aug 7;5(2):130-2. doi: 10.1016/j.stem.2009.07.004.

Abstract

In a recent report in Nature, Cordes et al. (2009) demonstrate that miR-143 and miR-145 modulate smooth muscle cell (SMC) plasticity in part by regulating key transcription factors involved in SMC fate determination.

MeSH terms

  • Animals
  • Cell Differentiation*
  • Heterogeneous-Nuclear Ribonucleoprotein Group A-B / metabolism*
  • Humans
  • MicroRNAs / metabolism*
  • Myocytes, Smooth Muscle / cytology
  • Myocytes, Smooth Muscle / metabolism*
  • Nuclear Proteins / metabolism*
  • Repressor Proteins / metabolism*
  • Serum Response Factor / metabolism*
  • Trans-Activators / metabolism*

Substances

  • Heterogeneous-Nuclear Ribonucleoprotein Group A-B
  • MicroRNAs
  • Nuclear Proteins
  • Repressor Proteins
  • Serum Response Factor
  • Trans-Activators
  • myocardin
  • Hnrnpab protein, mouse