Emergence of oseltamivir-resistant influenza A H1N1 virus during the 2007-2008 winter season in Luxembourg: clinical characteristics and epidemiology

Antiviral Res. 2009 Oct;84(1):91-4. doi: 10.1016/j.antiviral.2009.08.001. Epub 2009 Aug 7.

Abstract

Human cases of oseltamivir-resistant influenza A H1N1 virus emerging in 2007-2008 in Luxembourg were not associated with treatment, prophylaxis or stockpiling of oseltamivir. Following initial local seeding, oseltamivir-resistant strains spread synchronously to sensitive strains causing a similar epidemiology and clinical symptoms.

MeSH terms

  • Adolescent
  • Adult
  • Antiviral Agents / therapeutic use*
  • Child
  • Child, Preschool
  • Drug Resistance, Viral*
  • Female
  • Humans
  • Influenza A Virus, H1N1 Subtype / classification
  • Influenza A Virus, H1N1 Subtype / drug effects
  • Influenza A Virus, H1N1 Subtype / isolation & purification*
  • Influenza A Virus, H1N1 Subtype / physiology
  • Influenza, Human / drug therapy
  • Influenza, Human / epidemiology*
  • Influenza, Human / virology
  • Luxembourg / epidemiology
  • Male
  • Molecular Sequence Data
  • Oseltamivir / therapeutic use*
  • Phylogeny
  • Seasons
  • Young Adult

Substances

  • Antiviral Agents
  • Oseltamivir