Sickle cell disease (SCD) is the most common inherited disease worldwide and is responsible for a massive health burden. Its main clinical feature is severe pain that is unpredictable and recurrent, and this, in addition to the other acute and chronic features of SCD, may have a huge impact on the quality of life of both the patient and their families and carers. We consider medical and psychological methods of pain management in SCD, drawing on recently published UK Standards of Care, and also consider the effect of SCD on quality of life.