Abstract
An acetone extract of the fruits of the Taiwanese medicinal plant Schisandra arisanensis has yielded 11 new oxygenated lignans. Four of these, named arisantetralones A-D (1-4), possess the aryltetralone skeleton, while the other seven, named arisanschinins F-L (5-11), are polyoxygenated C(18)-dibenzocyclooctadiene lignans. Structures were determined on the basis of spectroscopic analyses, especially 2D-NMR techniques. The structure of compound 1 was confirmed by X-ray crystallographic analysis. Immunomodulatory activity of the isolated lignans was tested and evaluated.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Crystallography, X-Ray
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Fruit / chemistry
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Humans
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Immunologic Factors / blood
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Immunologic Factors / chemistry
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Immunologic Factors / isolation & purification*
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Immunologic Factors / pharmacology
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Lignans / blood
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Lignans / chemistry
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Lignans / isolation & purification*
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Lignans / pharmacology
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Models, Molecular
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Molecular Conformation
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Oxygen / chemistry
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Plants, Medicinal / chemistry*
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Schisandra / chemistry*
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Taiwan
Substances
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Immunologic Factors
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Lignans
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Oxygen