Retiform hemangioendothelioma: presentation of a case expressing D2-40

J Cutan Pathol. 2009 Sep;36(9):987-90. doi: 10.1111/j.1600-0560.2009.01161.x.

Abstract

Retiform hemangioendothelioma (RH) is a low-grade angiosarcoma with low metastatic risk, usually occurring as a single lesion on the trunk or extremity in middle-aged adults. Histopathology shows a distinctive pattern with arborizing blood vessels arranged in a retiform pattern (similar to rete testis tissue) and focal papillae with fibrosclerotic (hyaline) cores. The blood vessels are lined by comparatively monomorphic endothelial cells, frequently presenting a hobnail pattern. We report a case of RH presenting as an indolent brownish plaque on the back of a 17-year-old male. Surgical resection and sentinel lymph node biopsy showed no evidence of metastasis. In contrast to the recent literature, this case of RH showed positivity for D2-40, a marker of lymphatic endothelium. We also report ultrastructural findings for this case of RH.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Antibodies, Monoclonal / metabolism*
  • Antibodies, Monoclonal, Murine-Derived
  • Biomarkers, Tumor / analysis
  • Hemangioendothelioma / metabolism
  • Hemangioendothelioma / pathology*
  • Hemangioendothelioma / surgery
  • Humans
  • Male
  • Microscopy, Electron, Transmission
  • Skin Neoplasms / metabolism
  • Skin Neoplasms / pathology*
  • Skin Neoplasms / surgery

Substances

  • Antibodies, Monoclonal
  • Antibodies, Monoclonal, Murine-Derived
  • Biomarkers, Tumor
  • monoclonal antibody D2-40