Kinetic patterns of Candida albicans germ tube antibody in critically ill patients: influence on mortality

Clin Vaccine Immunol. 2009 Oct;16(10):1527-8. doi: 10.1128/CVI.00183-09. Epub 2009 Aug 12.

Abstract

The influence of kinetic patterns of Candida albicans germ tube antibodies (CAGTA) on mortality was analyzed in six intensive care units. Statistically significant lower mortality rates were found in patients with patterns of increasing CAGTA titers who had been treated with antifungal agents. Thus, antifungal treatment should be considered when CAGTA titers are increasing in critically ill patients.

Publication types

  • Multicenter Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antibodies, Fungal / blood*
  • Antifungal Agents / therapeutic use
  • Candida albicans / immunology*
  • Candidiasis / diagnosis
  • Candidiasis / drug therapy
  • Candidiasis / immunology*
  • Candidiasis / mortality*
  • Critical Illness
  • Humans
  • Kinetics
  • Retrospective Studies
  • Risk Factors
  • Spain / epidemiology

Substances

  • Antibodies, Fungal
  • Antifungal Agents