Low N-acetyltransferase 2 activity in isoniazid-associated acute hepatitis requiring liver transplantation

Transpl Int. 2010 Feb;23(2):231-3. doi: 10.1111/j.1432-2277.2009.00921.x. Epub 2009 Jul 20.

Authors

Jakob P Cramer, Ansgar W Lohse, Gerd D Burchard, Lutz Fischer, Björn Nashan, Mathias Zimmermann, Andreas Marx, Stefan Kluge

PMID: 19686464
DOI: 10.1111/j.1432-2277.2009.00921.x

No abstract available

Publication types

Case Reports
Letter

MeSH terms

Antitubercular Agents / adverse effects*
Antitubercular Agents / pharmacokinetics
Arylamine N-Acetyltransferase / deficiency*
Arylamine N-Acetyltransferase / genetics*
Chemical and Drug Induced Liver Injury / enzymology*
Chemical and Drug Induced Liver Injury / genetics
Chemical and Drug Induced Liver Injury / pathology
Chemical and Drug Induced Liver Injury / surgery*
Female
Genes, MDR
Genetic Variation
Heterozygote
Humans
Isoniazid / adverse effects*
Isoniazid / pharmacokinetics
Liver Transplantation*
Middle Aged
Mutation
Risk Factors

Substances

Antitubercular Agents
Arylamine N-Acetyltransferase
NAT2 protein, human
Isoniazid