Abstract
This study aimed to evaluate the 4-(6'-thiopurine)-7-chloroquinoline, a novel quinoline/6-thiopurine conjugate, for the treatment of Gallus gallus experimentally infected with Plasmodium juxtanucleare, an avian malaria agent. The avian group treated with 4-(6'-thiopurine)-7-chloroquinoline showed a significative parasite clearance and maintained a low level of parasitaemia, when compared with the untreated control group and to the chloroquine treated avian group.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Animals
-
Antimalarials / chemical synthesis
-
Antimalarials / chemistry
-
Antimalarials / pharmacology*
-
Chickens
-
Chloroquine / chemistry
-
Chloroquine / pharmacology
-
Disease Models, Animal
-
Malaria, Avian / drug therapy
-
Parasitemia / drug therapy
-
Plasmodium / drug effects*
-
Purines / chemical synthesis
-
Purines / chemistry
-
Purines / pharmacology*
-
Quinolines / chemical synthesis
-
Quinolines / chemistry
-
Quinolines / pharmacology*
Substances
-
4-(6'-thiopurine)-7-chloroquinoline
-
Antimalarials
-
Purines
-
Quinolines
-
Chloroquine