Endoscopic mucosal resection (EMR) and endoscopic piecemeal resection (EPMR) are therapeutic options widely accepted for the treatment of colon adenoma, intramucosal cancer and minimally invasive submucosal cancer. Our retrospective investigation revealed that single EMR or EPMR with 2-channel procedure cured 913 (96.6%) of 945 flat and depressed tumors, verifying the significant role of certain procedures in the therapeutic strategy for colorectal neoplasm. Predicting the invasion depth and fibrotic change before resection are proposed to be necessary for improving complete resection rate of first EMR or EPMR. Hood, 2-channel method and the combination of EMR and circumferential mucosal incision are regarded to be practical procedures on EPMR.