Field deployable technique for 90Sr emergency bioassay

Radiat Prot Dosimetry. 2009 Sep;136(2):82-6. doi: 10.1093/rpd/ncp153. Epub 2009 Aug 19.

Abstract

Rapid bioassay is very important for immediate and near-term consequence management, which includes identifying contaminated individuals and providing necessary medical intervention during a radiological or nuclear emergency. This paper reports the application of a newly developed bioassay technique for (90)Sr in urine on a field deployable instrument, the Triathler. Performance of this field technique for sensitivity, accuracy and repeatability is evaluated against bioassay criteria (ANSI N13.30). This field technique offers the following analytical merits: (1) minimum detectable activity of 121 Bq l(-1) when 20 ml of urine is used; (2) relative bias of 11.1 % and relative precision of 3.2 % at the level of 45 Bq per 20 ml of urine and (3) sample turnaround time of less than 1 h. The technique meets the requirements for emergency bioassay when a committed effective dose of 0.5 Sv is used as the action dose threshold for medical intervention. Sample throughput can be significantly improved if this technique is automated.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Biological Assay*
  • Humans
  • Radiation Monitoring / methods*
  • Sensitivity and Specificity
  • Strontium Radioisotopes / analysis*
  • Urinalysis / methods*
  • Urine / chemistry*

Substances

  • Strontium Radioisotopes