Tumor necrosis factor alpha gene polymorphism in multiple sclerosis and optic neuritis

L Fugger; N Morling; M Sandberg-Wollheim; L P Ryder; A Svejgaard

doi:10.1016/0165-5728(90)90140-i

Tumor necrosis factor alpha gene polymorphism in multiple sclerosis and optic neuritis

J Neuroimmunol. 1990 Apr;27(1):85-8. doi: 10.1016/0165-5728(90)90140-i.

Authors

L Fugger¹, N Morling, M Sandberg-Wollheim, L P Ryder, A Svejgaard

Affiliation

¹ Department of Clinical Immunology, State University Hospital (Rigshospitalet), Copenhagen, Denmark.

PMID: 1969423
DOI: 10.1016/0165-5728(90)90140-i

Abstract

The NcoI tumor necrosis factor (TNF alpha) polymorphism was studied in relapsing/remitting multiple sclerosis and monosymptomatic optic neuritis. The frequency of the NcoI marker phenotypes did not differ between healthy controls and the two disease groups. No extra or missing DNA fragments were observed in the disease groups when compared with controls.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Adult
Alleles
Child
Genes*
Humans
Multiple Sclerosis / genetics*
Multiple Sclerosis / physiopathology
Optic Neuritis / genetics*
Phenotype
Polymorphism, Genetic*
Polymorphism, Restriction Fragment Length
Tumor Necrosis Factor-alpha / genetics*

Substances

Tumor Necrosis Factor-alpha