Rhodium-catalyzed mono- and divinylation of 1-phenylpyrazoles and related compounds via regioselective C-H bond cleavage

J Org Chem. 2009 Sep 18;74(18):7094-9. doi: 10.1021/jo901485v.

Abstract

The selective 2-mono- and 2,6-divinylations of (N-containing heteroaryl)benzenes can be achieved effectively through rhodium-catalyzed oxidative coupling reactions with alkenes. The installation of two different vinyl groups is also possible by a simple one-pot manner. Thus, a series of 1,3-divinylbenzene derivatives, some of which exhibit solid-state fluorescence, is readily prepared.