New reusable Celite/ethylene glycol cartridges for selective chromatography of steroids before immunoassay

Clin Biochem. 2009 Nov;42(16-17):1735-8. doi: 10.1016/j.clinbiochem.2009.08.006. Epub 2009 Aug 21.

Abstract

Objectives: Preparation of reusable and easy to handle Celite chromatographic columns.

Design and methods: Weighting precise Celite quantities in cartridges and introducing ethylene glycol methanol solutions. The chromatographic solvents pass throughout Celite under negative pressure.

Results: These new minicolumns are reusable. The steroid recoveries' coefficients of variation are less than 10%, and the steroid separation is good.

Conclusions: The reusable Celite cartridge use before steroid immunoassays is easier and less time-consuming than classical glass Celite minicolumns.

MeSH terms

  • Chromatography / methods*
  • Ethylene Glycol / chemistry*
  • Immunoassay / methods*
  • Reproducibility of Results

Substances

  • Ethylene Glycol