Phylogenetic analysis of rubella viruses isolated in 2008 outbreak in Argentina

J Clin Virol. 2009 Nov;46(3):286-9. doi: 10.1016/j.jcv.2009.07.018. Epub 2009 Aug 22.

Abstract

Background: A rubella outbreak was recorded in Buenos Aires during 2008.

Objectives: The objective of this communication is to present the genetic and phylogenetic analyses of wild-type RUBV circulating in Buenos Aires during the 2008 outbreak.

Study design: Throat swab samples collected from patients diagnosed with rubella between June 2008 and December 2008 were inoculated in cell culture and 23 isolates were sequenced.

Results: Phylogenetic analysis of the WHO-recommended window (nt 8731-9469) of the E1 envelope glycoprotein was performed and all isolates clustered with the 2B genotype.

Conclusions: Genotype 2B seems to be endemically circulating in the Southern cone of Latin America, thus causing recent outbreaks.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Amino Acid Sequence
  • Argentina / epidemiology
  • Child
  • Evolution, Molecular
  • Humans
  • Molecular Epidemiology / methods
  • Pharynx / virology
  • Phylogeny
  • Reverse Transcriptase Polymerase Chain Reaction
  • Rubella / epidemiology
  • Rubella / virology*
  • Rubella virus / genetics*
  • Rubella virus / isolation & purification
  • Sequence Alignment
  • Sequence Analysis, DNA