Abstract
The first phytochemical investigation of the fruits of Angelica lucida has led to the isolation and characterization of five known coumarins (imperatorin, isoimperatorin, heraclenol, oxypeucedanin hydrate and heraclenin). All isolated compounds were identified by means of spectral and literature data. The extracts and the isolated constituents from A. lucida have been also evaluated for their antimicrobial activity against six Gram positive and negative bacteria, two oral pathogens and three human pathogenic fungi, exhibiting an interesting antimicrobial profile.
MeSH terms
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Angelica / chemistry*
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Anti-Infective Agents / chemistry*
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Anti-Infective Agents / isolation & purification
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Anti-Infective Agents / pharmacology*
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Benzopyrans / chemistry
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Benzopyrans / isolation & purification
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Benzopyrans / pharmacology
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Coumarins / chemistry*
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Coumarins / isolation & purification
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Coumarins / pharmacology*
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Fruit / chemistry
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Fungi / drug effects
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Furans / chemistry
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Furans / isolation & purification
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Furans / pharmacology
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Furocoumarins / chemistry
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Furocoumarins / isolation & purification
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Furocoumarins / pharmacology
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Gram-Negative Bacteria / drug effects
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Gram-Positive Bacteria / drug effects
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Magnetic Resonance Spectroscopy
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Microbial Sensitivity Tests
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Molecular Structure
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Plant Extracts / chemistry
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Plant Extracts / isolation & purification
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Plant Extracts / pharmacology
Substances
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Anti-Infective Agents
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Benzopyrans
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Coumarins
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Furans
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Furocoumarins
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Plant Extracts
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isoimperatorin
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heraclenol
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heraclenin
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imperatorin
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oxypeucadanin